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Structure-function relationship of FUS, an RNA-binding protein, in DNA repair

Evgeniya Mamontova
Molecular biology. Université Paris-Saclay; Novosibirsk State Technical University (Novosibirsk, Russie), 2023. English. ⟨NNT : 2023UPASL051⟩
Theses tel-04195352v1
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Targeting RNA:protein interactions with an integrative approach leads to the identification of potent YBX1 inhibitors

Krystel El Hage , Nicolas Babault , Olek Maciejak , Bénédicte Desforges , Pierrick Craveur , et al.
eLife, 2023, 12, pp.e80387. ⟨10.7554/eLife.80387⟩
Journal articles hal-03955052v1

Targeting the Major Groove of the Palindromic d(GGCGCC)2 Sequence by Oligopeptide Derivatives of Anthraquinone Intercalators

Krystel El Hage , Giovanni Ribaudo , Louis Lagardère , Alberto Ongaro , Philippe H. Kahn , et al.
Journal of Chemical Information and Modeling, 2022, 62 (24), pp.6649-6666. ⟨10.1021/acs.jcim.2c00337⟩
Journal articles hal-03624169v1
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Caractérisation de l'interaction entre FUS et TDP-43, deux protéines de liaison à l'ARN impliquées dans les maladies neurodégénératives

Clément Demongin
Biochimie [q-bio.BM]. Université Paris-Saclay, 2022. Français. ⟨NNT : 2022UPASL039⟩
Theses tel-03783244v1
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Structural convergence for tubulin binding of CPAP and vinca domain microtubule inhibitors

Valérie Campanacci , Agathe Urvoas , Liza Ammar Khodja , Magali Aumont-Nicaise , Magali Noiray , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2022, 119, pp.e2120098119. ⟨10.1073/pnas.2120098119⟩
Journal articles hal-03431978v2
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A Sub-Micromolar MraYAA Inhibitor with an Aminoribosyl Uridine Structure and a (S,S)-Tartaric Diamide: Synthesis, Biological Evaluation and Molecular Modeling

Martin Oliver , Laurent Le Corre , Mélanie Poinsot , Michaël Bosco , Hongwei Wan , et al.
Molecules, 2022, 27 (6), pp.1769. ⟨10.3390/molecules27061769⟩
Journal articles hal-03632451v1

Identification of a small molecule splicing inhibitor targeting UHM domains

Asaki Kobayashi , Marie‐jeanne Clément , Pierrick Craveur , Krystel El Hage , Jean de Matha Salone , et al.
FEBS Journal, 2021, 289 (3), pp.682-698. ⟨10.1111/febs.16199⟩
Journal articles hal-03354012v1
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The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation

Juan Carlos Rengifo-Gonzalez , Krystel El Hage , Marie-Jeanne Clément , Emilie Steiner , Vandana Joshi , et al.
eLife, 2021, 10, pp.e.67605. ⟨10.7554/eLife.67605⟩
Journal articles hal-03343496v1
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Getting to know each other: PPIMem, a novel approach for predicting transmembrane protein-protein complexes

Georges Khazen , Aram Gyulkhandanian , Tina Issa , Rachid Maroun
Computational and Structural Biotechnology Journal, 2021, 19, pp.5184-5197. ⟨10.1016/j.csbj.2021.09.013⟩
Journal articles hal-03354041v1
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YB-1 unwinds mRNA secondary structures in vitro and negatively regulates stress granule assembly in HeLa cells

Karina Budkina , Krystel El hage , Marie-Jeanne Clément , Bénédicte Desforges , Ahmed Bouhss , et al.
Nucleic Acids Research, 2021, 49 (17), pp.10061-10081. ⟨10.1093/nar/gkab748⟩
Journal articles hal-03333572v1
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Interplay between TDP-43 and FUS in protein assemblies-Influence of mRNA on the aggregation process

Clément Demongin , Guillaume Lambert , Vandana Joshi , David Pastre , Loic Hamon
Molecular Neurodegeneration and Therapeutic Approaches – Virtual Event, Jan 2021, Online, France. 2021
Conference poster hal-03195903v1
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Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain

Anastasiia Samsonova , Krystel El Hage , Bénédicte Desforges , Vandana Joshi , Marie-Jeanne Clément , et al.
Communications Biology, 2021, 4 (1), pp.359. ⟨10.1038/s42003-021-01862-3⟩
Journal articles hal-03176308v1
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ITSN1 regulates SAM68 solubility through SH3 domain interactions with SAM68 proline-rich motifs

S. Pankivskyi , D. Pastré , E. Steiner , V. Joshi , A. Rynditch , et al.
Cellular and Molecular Life Sciences, 2021, 78, pp.1745-1763. ⟨10.1007/s00018-020-03610-y⟩
Journal articles hal-02968869v1
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Synthesis, biological evaluation and molecular modeling of urea-containing MraY inhibitors

Martin Oliver , Laurent Le Corre , Mélanie Poinsot , Alessandra Corio , Léa Madegard , et al.
Organic & Biomolecular Chemistry, 2021, 19 (26), pp.5844-5866. ⟨10.1039/D1OB00710F⟩
Journal articles hal-03432617v1
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Catalysis and specificity of the polycondensation of aminopropyltrimethoxysilane on nucleic acids

Nathalie Jarroux , Marie-Jeanne Clément , Cédric Przybylski , Olek Maciejak , Patrick A. Curmi , et al.
GSC Biological and Pharmaceutical Sciences, 2020, 13 (2), pp.290-299. ⟨10.30574/gscbps.2020.13.2.0332⟩
Journal articles hal-03702917v1

Water Dynamics Around Proteins: T- and R-States of Hemoglobin and Melittin

Marco Pezzella , Krystel El Hage , Michiel Niesen , Sucheol Shin , Adam Willard , et al.
Journal of Physical Chemistry B, 2020, 124 (30), pp.6540-6554. ⟨10.1021/acs.jpcb.0c04320⟩
Journal articles hal-02969027v1
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Squalamine and Aminosterol Mimics Inhibit the Peptidoglycan Glycosyltransferase Activity of PBP1b

Adrien Boes , Jean-Michel Brunel , Adeline Derouaux , Frederic Kerff , Ahmed Bouhss , et al.
Antibiotics, 2020, 9 (7), pp.373. ⟨10.3390/antibiotics9070373⟩
Journal articles hal-03085034v1

Quantum-Chemistry based design of halobenzene derivatives with augmented affinities for the HIV-1 viral G4/C16 base-pair.

Perla El Darazi , Léa El Khoury , Krystel El Hage , Richard G. Maroun , Zeina Hobaika , et al.
Frontiers in Chemistry, 2020, 8, pp.440. ⟨10.3389/fchem.2020.00440⟩
Journal articles hal-02377718v1
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Analysis of protein missense alterations by combining sequence‐ and structure‐based methods

Aram Gyulkhandanyan , Alireza R. Rezaie , Lubka Roumenina , Nathalie Lagarde , Veronique Fremeaux‐bacchi , et al.
Molecular Genetics & Genomic Medicine, 2020, 8 (4), pp.e1166. ⟨10.1002/mgg3.1166⟩
Journal articles hal-03246847v1

A complex view of GPCR signal transduction: Molecular dynamics of the histamine H3 membrane receptor

L. Herrera-Zúñiga , L. Moreno-Vargas , L. Ballaud , J. Correa-Basurto , D. Prada-Gracia , et al.
Preprints, Working Papers, ... hal-02968906v1
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Inhibition of Transcription Induces Phosphorylation of YB-1 at Ser102 and Its Accumulation in the Nucleus

Dmitry Kretov , Daria Mordovkina , Irina Eliseeva , Dmitry Lyabin , Dmitry Polyakov , et al.
Cells, 2020, 9 (1), pp.104. ⟨10.3390/cells9010104⟩
Journal articles hal-02968925v1
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Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA

Maria Sukhanova , Anastasia Singatulina , David Pastre , Olga Lavrik
International Journal of Molecular Sciences, 2020, 21 (19), pp.7020. ⟨10.3390/ijms21197020⟩
Journal articles hal-02968942v1
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Regulation of Poly(ADP-Ribose) Polymerase 1 Activity by Y-Box-Binding Protein 1

Konstantin Naumenko , Mariya Sukhanova , Loic Hamon , Tatyana Kurgina , Elizaveta Alemasova , et al.
Biomolecules, 2020, 10 (9), pp.1325. ⟨10.3390/biom10091325⟩
Journal articles hal-02968966v1
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Physiological roles of antisense RNAs in prokaryotes

Maxence Lejars , Asaki Kobayashi , Eliane Hajnsdorf
Biochimie, 2019, 164, pp.3-16. ⟨10.1016/j.biochi.2019.04.015⟩
Journal articles hal-03026252v1
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Targeting Degradation of EGFR through the Allosteric Site Leads to Cancer Cell Detachment-Promoted Death

Melkon Iradyan , Nina Iradyan , Philippe Hulin , Artur Hambardzumyan , Aram Gyulkhandanyan , et al.
Cancers, 2019, 11 (8), pp.1094. ⟨10.3390/cancers11081094⟩
Journal articles hal-02321259v1

U2AF65 assemblies drive sequence-specific splice site recognition

Manel Tari , Valerie Manceau , Jean Matha Salone , Asaki Kobayashi , David Pastre , et al.
EMBO Reports, 2019, 20 (8), pp.e47604. ⟨10.15252/embr.201847604⟩
Journal articles hal-02178664v1

A Single-Molecule Atomic Force Microscopy Study of PARP1 and PARP2 Recognition of Base Excision Repair DNA Intermediates

Maria Sukhanova , Loic Hamon , Mikhail Kutuzov , Vandana Joshi , Sanae Abrakhi , et al.
Journal of Molecular Biology, 2019, 431 (15), pp.2655-2673. ⟨10.1016/j.jmb.2019.05.028⟩
Journal articles hal-02165889v1
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PARP-1 Activation Directs FUS to DNA Damage Sites to Form PARG-Reversible Compartments Enriched in Damaged DNA

Anastasia Singatulina , Loic Hamon , Maria Sukhanova , Bénédicte Desforges , Vandana Joshi , et al.
Cell Reports, 2019, 27 (6), pp.1809-1821. ⟨10.1016/j.celrep.2019.04.031⟩
Journal articles hal-02167709v1
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YB-1, an abundant core mRNA-binding protein, has the capacity to form an RNA nucleoprotein filament: a structural analysis

Dmitry Kretov , Marie-Jeanne Clément , Guillaume Lambert , Dominique Durand , Dmitry Lyabin , et al.
Nucleic Acids Research, 2019, 47 (6), pp.3127-3141. ⟨10.1093/nar/gky1303⟩
Journal articles hal-02114790v1
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Bacterial Lipid II Analogs: Novel In Vitro Substrates for Mammalian Oligosaccharyl Diphosphodolichol Diphosphatase (DLODP) Activities

Ahmad Massarweh , Michael Bosco , Isabelle Chantret , Thibaut Léger , Layla Jamal , et al.
Molecules, 2019, 24 (11), pp.2135. ⟨10.3390/molecules24112135⟩
Journal articles hal-02172947v1