Sandwich panels are used in many industries for their lightweight compared to high strength. Most of the sandwich panels application are bending and compression, which relies on the core type of the panel. Widely used in additive manufacturing is pyramid cell cores. In this article, two new cores, the reinforced pyramid cell model and the C-half circle cell model, are proposed to replace the pyramidal core and to verify their advantages and disadvantages with respect to it compression and in bending. The comparison was done in the ABAQUS simulation. A semi-analytical method was used as well as experimental tests were carried out to verify the numerical simulation on ABAQUS. The results have been validated, the difference remains below 10%. According to the simulations, the deformation of the skin of the half circle cell panel decreases by 15% in compression while the deflection of the reinforced pyramid cell panel decreases by 26% in bending compared to the pyramid cell panel. However, the most effective results in absorbing compression are half circle cell which is allowed to make impact insulation.