In this article, a continuous-discrete high gain observer with a proportional integral (PI) output predictor structure is designed for a class of nonlinear systems subject to sampled-delayed data measurements. To counteract the effect of the well-known sensitivity of the high gain observer to the noise measurements, a novel PI output predictor structure is proposed. The uniform ultimate boundedness (UUB) of the proposed observer is demonstrated by means of Lyapunov function and small gain method. The effectiveness of our proposed observer is demonstrated through numerical simulations and performances comparison with previous observer design methods in the literature.