BioHAN: a Knowledge-based Heterogeneous Graph Neural Network for precision medicine on transcriptomic data - Université d'Évry
Pré-Publication, Document De Travail Année : 2023

BioHAN: a Knowledge-based Heterogeneous Graph Neural Network for precision medicine on transcriptomic data

Résumé

Deep-learning models promisingly benefit precision medicine in automatically solving phenotype prediction tasks on high-throughout omic data. However, their lack of interpretability limits their development in healthcare. Some studies are leveraging high-level human comprehensible biological concepts to increase the interpretability of these models, but interpretability is still not direct, and managing different knowledge types is limited. We propose BioHAN, a heterogeneous and selfexplaining graph neural network, using a self-attention mechanism. The heterogeneous input graph has a central gene graph and auxiliary graphs that compensate for the sparsity of the central graph. Experiments on a real dataset show that BioHAN has similar accuracy to the non-interpretable state-of-the-art and provides automatic explanations by listing the most relevant genes and identifying the most important concept-based neighbors of these genes. All these features should make BioHAN a functional tool to clinicians.
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Dates et versions

hal-04092210 , version 1 (09-05-2023)

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  • HAL Id : hal-04092210 , version 1

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Victoria Bourgeais, Farida Zehraoui, Blaise Hanczar. BioHAN: a Knowledge-based Heterogeneous Graph Neural Network for precision medicine on transcriptomic data. 2023. ⟨hal-04092210⟩
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